Assessing Plunger Stopper Movement Under Low Pressure and Variable Temperature Conditions

Assessing Plunger Stopper Movement Under Low Pressure and Variable Temperature Conditions

This poster presentation examines the impact of low-pressure environments and temperature variation on plunger stopper movement in prefilled syringes, a key risk factor for container closure integrity, sterility, and product quality. Originally presented by Smithers expert Charlotte Utting at the PDA Universe of Pre-Filled Syringes and Injection Devices Conference 2025, the work outlines a controlled experimental approach to simulate air transport conditions and evaluate stopper displacement under defined altitude and temperature scenarios.

What this poster presentation covers

  • Key risks associated with unintended plunger stopper movement
  • The influence of pressure and temperature during air transport and storage
  • An overview of the experimental setup used to simulate altitude conditions
  • Summary findings related to sterile zone acceptance criteria
  • Considerations for future testing and industry standards

Download the Poster

Download the full poster presentation to review the methodology, results, and implications for prefilled syringe performance during transport and storage.
Smithers_PDA-Poster_Charlotte-Utting_2025
Smithers_PDA-Poster_Charlotte-Utting_2025
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